Imaging In Cns Drug Discovery And Development (libro En Ingl

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PRODUCTO:

Nombre: Imaging in CNS Drug Discovery and Development (Libro en Inglés)
Marca: Springer

DESCRIPCIÓN:

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping.Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling (monics) as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye. Contraportada Imaging is a key area of translational research that provides a unique bridge from the laboratory to the clinic as the same techniques and technologies can applied across the various phases of drug development. Neuroimaging is now central to research and drug development in the neurosciences since it can be used to detect the pharmacological and physiological consequences of drug action within the living brain. Today neuroimaging is used primarily as a biomarker to help optimize our decision-making processes. Neuroimaging tools and technologies can be used to select drug candidates, confirm they engage their targets, link occupancy to biology and then, in a translational fashion, be used to help design the best clinical studies that truly test therapeutic hypotheses.Topics covered include: The role of imaging in drug developmentImaging approaches including structural, functional, molecular and chemical imagingImaging drug action including neuroreceptor mapping to examine drug occupancy characteristics, the involvement of specific neurotransmitter systems in CNS diseases and mechanisms of actionFunctional mapping to provide pharmacodynamic evidence of central activity, CNS fingerprinting of the neuroanatomy of drug effects and disease drug interactions Imaging disease states in preclinical and clinical domainsNeuroimaging today is all about the need to identify the best molecules, doses and hypotheses to advance into later stage long term extensive clinical trials that can often be confounded by high placebo response rates. Better decision making in early development allows resources to be focused on the drug candidates and therapeutic hypotheses that have the highest probability of success so that we can bring medical advances to patients as quickly as possible. Imaging in CNS Drug Discovery and Development was written by a group of preeminent international experts in the field of imaging. Biografía del autor David Borsook, MD, Ph.D., trained in medicine and neurobiology at the University of the Witwatersrand, Medical School, Johannesburg, South Africa. He graduated in 1980. Following his internship he trained in Neurology at Boston City Hospital and then was the first Pain Fellow at the Massachusetts General Hospital, Department of Neurology. He subsequently was the Director of the Pain Center at the Hospital from 1994 - 2004. He has completed doctoral studies in Neurobiology and later started the Pain Imaging Program in the Department of Radiology at Massachusetts General Hospital. In 2002 he led an effort to cofound a Biotech - Descartes Therapeutics Inc, with his colleague Lino Becerra Ph.D. to use imaging in drug development, where he was Senior Vice President and Chief Scientific Officer. He currently directs an integrated imaging program - Pain & Analgesia Imaging Neuroscience (p.a.i.n.) Group at three Harvard Medical School Affiliated Hospitals, Massachusetts General Hospital, McLean Hospital and Children's Hospital Boston. A component of thi

CARACTERÍSTICAS PRINCIPALES:

-Libro Impreso
-Edición:
-Editorial: Springer
-Autor: Borsook, David

MÁS DETALLES:

Tiempo de entrega: 10 días
Peso del paquete: 1 kg
Medidas: 5 cm x 22 cm x 27 cm cm
Material: Papel
Modelo: 9781441901330
Meses de garantía: 1
Garantía: Por defectos de fabricación
Condición: Nuevo
Color: Multicolor
Nombre de color: Multicolor
ASIN: 1441901337
País de producción: United States
Encuadernado: Pasta dura
Editorial: Springer
Titulo del libro: Imaging in CNS Drug Discovery and Development
Autor: Borsook, David
Fecha de publicación: 2009
Idioma: Inglés
Número de páginas: 396
ISBN-13: 9781441901330
Edad mínima sugerida: 6
Contenido del paquete: 1 pieza
SKU: 9781441901330