Centromere (libro En Inglés)

Descripción

PRODUCTO:

Nombre: Centromere (Libro en Inglés)
Marca: Springer

DESCRIPCIÓN:

The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and through its centromere DNA-protein complex known as the kinetochore binds spindle microtubules to bring about accurate chromosome movements. Despite this conserved function, centromeres exhibit dramatic difference in structure, size, and complexity. Extensive studies on centromeric DNA revealed its rapid evolution resulting often in significant difference even among closely related species. Such a plasticity of centromeric DNA could be explained by epigenetic c- trol of centromere function, which does not depend absolutely on primary DNA sequence. According to epigenetic centromere concept, which is thoroughly d- cussed by Tanya Panchenko and Ben Black in Chap. 1 of this book, centromere activation or inactivation might be caused by modifications of chromatin. Such acquired chromatin epigenetic modifications are then inherited from one cell di- sion to the next. Concerning centromere-specific chromatin modification, it is now evident that all centromeres contain a centromere specific histone H3 variant, CenH3, which replaces histone H3 in centromeric nucleosomes and provides a structural basis that epigenetically defines centromere and differentiates it from the surrounding chromatin. Recent insights into the CenH3 presented in this chapter add important mechanistic understanding of how centromere identity is initially established and subsequently maintained in every cell cycle. Contraportada The centromere is a chromosomal locus that regulates the proper pairing and segregation of the chromosomes during cell division. Despite their conserved, essential function, centromeres are characterized by the rapid evolution of both centromeric DNA and proteins. This book presents current views on centromere structure and identity. It deals with the epigenetic concept of centromere establishment and maintenance as well as with the role of DNA and centromeric transcripts in centromere formation and function. Special emphasis is placed on centromere evolution: different evolutionary models are discussed in detail and the latest research on the evolution of new centromeres and neocentromeres is presented.

CARACTERÍSTICAS PRINCIPALES:

-Libro Impreso
-Edición:
-Editorial: Springer
-Autor: Ugarkovic, Durdica

MÁS DETALLES:

Peso del paquete: 1 kg
Modelo: 9783642001819
Meses de garantía: 1
Garantía: Por defectos de fabricación
Condición: Nuevo
Color: Multicolor
Nombre de color: Multicolor
ASIN: 3642001815
Encuadernado: Pasta dura
Editorial: Springer
Titulo del libro: Centromere
Autor: Varios
Fecha de publicación: 2009
Idioma: Inglés
Número de páginas: 184
ISBN-13: 9783642001819
Edad mínima sugerida: 6
Contenido del paquete: 1 pieza
SKU: 9783642001819